Neutral Steroids in Urine during Pregnancy. Identification of Sulphate-Conjugated 3beta,15alpha-Dihydroxy-5alpha-pregnan-20-one, 3beta,15alpha-Dihydroxy-5beta-pregnan-20-one and 5-Pregnene-3beta,15beta,17alpha,20alpha-tetrol
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منابع مشابه
Effect of pregnancy and 5 -pregnan-3 -ol-20-one on atrial receptor afferent discharge in rats
Storey, Elaine, and Susan Kaufman. Effect of pregnancy and 5 -pregnan-3 -ol-20-one on atrial receptor afferent discharge in rats. Am J Physiol Regul Integr Comp Physiol 287: R1427–R1433, 2004. First published August 19, 2004; doi:10.1152/ajpregu.00693.2003.— The atrial volume reflex is attenuated in pregnancy. This may be mimicked by chronic administration of 5 -pregnan-3 -ol-20-one (pregnan). ...
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Twelve neuroactive and neuroprotective steroids, androgens and androgen precursors i.e. 3alpha,17beta-dihydroxy-5alpha-androstane, 3alpha-hydroxy-5alpha-androstan-17-one, 3alpha-hydroxy-5beta-androstan-17-one, androst-5-ene-3beta,17beta-diol, 3beta,17alpha-dihydroxy-pregn-5-en-20-one (17alpha-hydroxy-pregnenolone), 3beta-hydroxy-androst-5-en-17-one (dehydroepiandrosterone, DHEA), testosterone, ...
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The neurosteroid 3a-hyclroxy-5a-pregnan-20-one (3a,5a-THP) acts as a potent allosteric modulator and a direct activator of the GABA-chloride channel complex. This neurosteroid has also been found to protect against seizures that arise from blockade of the GABA-chloride channel complex. Because 3a,5a-THP protects against excitotoxin-induced seizure activity and because seizure activity has been ...
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Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that several specific actions of alcohol (ethanol) are mediated by the neurosteroid 3a-hydroxy-5a-pregnan-20-one (3a,5a-THP; allopregnanolone). Systemic alcohol administration elevates 3a,5a-THP levels in the cerebral ...
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Important gender differences in mood disorders result in a greater susceptibility for women. Accumulating evidence suggests a reciprocal modulation between the 5-hydroxytryptamine (5-HT) system and neuroactive steroids. Previous data from our laboratory have shown that during pregnancy, the firing activity of 5-HT neurons increases in parallel with progesterone levels. This study was undertaken...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1970
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1970.tb01145.x